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Book
Drug stability for pharmaceutical scientists
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ISBN: 0124115624 0124115489 1306412463 9780124115484 9780124115620 Year: 2014 Publisher: Amsterdam

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Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in


Book
Clinical electrocardiography
Author:
ISBN: 9780323087865 0323087868 0323091563 Year: 2012 Publisher: Philadelphia, Pa. London Saunders

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Clinical Electrocardiography: A Simplified Approach, 7th Edition goes beyond the simple waveform analysis to present ECGs as they are used in hospital wards, outpatient clinics, emergency departments, and intensive care units-where the recognition of normal and abnormal patterns is only the starting point in patient care. With Dr. Goldberger's renowned ability to make complex material easy to understand, you'll quickly grasp the fundamentals of ECG interpretation and analysis.Features indispensable self-tests on interpreting and using ECGs to formulate diagnoses. Presents co


Book
Alkaloid Synthesis
Author:
ISBN: 3642255280 3642255299 9783642255281 Year: 2012 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-.


Book
Amplification of chirality
Author:
ISSN: 03401022 ISBN: 9783540778691 3540778683 9783540778684 3540778691 Year: 2008 Volume: 284 Publisher: Berlin, Germany : Springer,

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Biomolecules in nature exhibit overwhelming one-handedness, often called homochirality, such as L-amino acids and D-sugars. Since the discovery of molecular chirality by Pasteur, the origins of chirality and the process le- ing to enantiopure biomolecules have attracted broad attention from many researchers. Several theories have been proposed for the origin of chirality in organic compounds, for example, left and right-circularly polarized light, sp- taneous absolute asymmetric synthesis, and chiral inorganic crystals such as quartz. However, the enantioenrichments induced by these mechanisms have been very low or even below detection levels. Thus, the process of ampli?cation of enantioenrichment is inevitable to reach enantiopure compounds. In 1953, Frank proposed a mechanism of asymmetric autocatalysis without mentioning any chemical structure. However, it then took over 40 years for us to discover asymmetric autocatalysis with ampli?cation of chirality in 1995. This book illustrates the recent aspects of ampli?cation of chirality by as- metric autocatalysis and by forming helical structures. The ?rst four chapters summarize experimental asymmetric autocatalysis with ampli?cation of en- tiopurity, the mechanism of asymmetric autocatalysis examined by NMR and calculation, the computer simulation models of the reaction mechanism of asymmetric autocatalysis, and the theoretical models of ampli?cation of c- rality. The last chapter deals with the ampli?cation of chirality by the f- mation of helical structures. However, the ampli?cation of enantiopurity in non-autocatalytic asymmetric reaction and the ampli?cation by enantiomer separation involving crystallization or sublimation are beyond the scope of this book.

Cell culture engineering
Authors: ---
ISSN: 07246145 ISBN: 9783540340065 3540340068 3540340076 9786610615520 1280615524 Year: 2006 Volume: 101 Publisher: Berlin ; Heidelberg : Springer-Verlag,

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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.

Cell separation : fundamentals, analytical, and preparative methods
Authors: --- ---
ISSN: 07246145 ISBN: 9783540752622 3540752625 3540752633 Year: 2007 Volume: 106 Publisher: Berlin, Germany ; New York, New York : Springer,


Book
Activity-Based Protein Profiling
Author:
ISSN: 03401022 ISBN: 3642283772 3642283780 9783642283772 Year: 2012 Volume: 324 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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M. B. Nodwell S. A. Sieber ABPP Methodology: Introduction and Overview J. Krysiak R. Breinbauer Activity-Based Protein Profiling for Natural Product Target Discovery P. P. Geurink L. M. Prely G. A. van der Marel R. Bischoff H. S. Overkleeft Photoaffinity Labeling in Activity-Based Protein Profiling W. P. Heal E. W. Tate Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis Y.-G. Kim A. Saghatelian Functional Analysis of Protein Targets by Metabolomic Approaches.  .


Book
Tissue Engineering III: Cell - Surface Interactions for Tissue Culture
Authors: --- ---
ISBN: 3642282814 3642282822 9783642282812 Year: 2012 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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J. S. Hayes E. M. Czekanska R. G. Richards The Cell-Surface Interaction Stefanie Michaelis Rudolf Robelek achim Wegener Studying Cell-Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques Kyobum Kim Diana M. Yoon Antonios G. Mikos F. Kurtis Kasper Harnessing Cell-Biomaterial Interactions for Osteochondral Tissue Regeneration Mathias Wilhelmi Bettina Giere Michael Harder Interaction of Cells with Decellularized Biological Materials Arie Bruinink Reto Luginbuehl Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations Margit Schulze Edda Tobiasch Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues Julia Will Lutz-Christian Gerhardt Aldo R. Boccaccini Bioactive Glass-Based Scaffolds for Bone Tissue Engineering Tali Re’em Smadar Cohen Microenvironment Design for Stem Cell Fate Determination Sonja Kress Anne Neumann Birgit Weyand Cornelia Kasper Stem Cell Differentiation Depending on Different Surfaces Frank Witte Ivonne Bartsch Elmar Willbold Designing the Biocompatibility of Biohybrids K. Wiegandt C. Goepfert R. Pörtner R. Janssen Interaction of Cartilage and Ceramic Matrix Debarun Das Ziyang Zhang Thomas Winkler Meenakshi Mour Christina I. Günter Michael M. Morlock Hans-Günther Machens Arndt F. Schilling Bioresorption and Degradation of Biomaterials.


Book
Electronic and Magnetic Properties of Chiral Molecules and Supramolecular Architectures
Authors: --- ---
ISBN: 3642181031 364218104X 9783642181030 Year: 2011 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Time-Dependent Density Functional Response Theory for Electronic Chiroptical Properties of Chiral Molecules, by Jochen Autschbach, Lucia Nitsch–Velasquez, and Mark Rudolph; Recent Theoretical and Experimental Advances in the Electronic Circular Dichroisms of Planar Chiral Cyclophanes, by Yoshihisa Inoue and Tadashi Mori; G-C Content Independent Long-Range Charge Transfer Through DNA, by Kiyohiko Kawai and Tetsuro Majima; Transfer of Chirality for Memory and Separation, by Rosaria Lauceri, Alessandro D’Urso, Angela Mammana and Roberto Purrello; Vibrational Circular Dichroism Spectroscopy 4 of Chiral Molecules, by Guochun Yang and Yunjie Xu; Spin Selective Electron Transmission Through Monolayers of Chiral Molecules, by Ron Naaman and Zeev Vager; Chiral Control of Current Transfer in Molecules, by Vered Ben-Moshe, David N. Beratan, Abraham Nitzan and Spiros S. Skourtis; Spin-Polarized Electron Induced Asymmetric Reactions in Chiral Molecules, by Richard A. Rosenberg.


Book
Advanced X-ray Crystallography
Author:
ISSN: 03401022 ISBN: 3642274064 3642274072 9783642274060 Year: 2012 Volume: 315 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Angelo Gavezzotti Computational Studies of Crystal Structure and Bonding   Piero Macchi Cryo-Crystallography: Diffraction at Low Temperature and More   Malcolm I. McMahon High-Pressure Crystallography   Panče Naumov Chemical X-Ray Photodiffraction: Principles, Examples, and Perspectives   Kenneth D. M. Harris Powder Diffraction Crystallography of Molecular Solids.

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