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Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in
Drug stability --- Chemistry --- Technology, Pharmaceutical --- Pharmacology --- Natural Science Disciplines --- Biological Science Disciplines --- Investigative Techniques --- Disciplines and Occupations --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry, Pharmaceutical --- Drug Stability --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Drug stability. --- Drugs --- Stability, Drug --- Stability
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Clinical Electrocardiography: A Simplified Approach, 7th Edition goes beyond the simple waveform analysis to present ECGs as they are used in hospital wards, outpatient clinics, emergency departments, and intensive care units-where the recognition of normal and abnormal patterns is only the starting point in patient care. With Dr. Goldberger's renowned ability to make complex material easy to understand, you'll quickly grasp the fundamentals of ECG interpretation and analysis.Features indispensable self-tests on interpreting and using ECGs to formulate diagnoses. Presents co
Arrhythmias, Cardiac --- Electrocardiography --- diagnosis --- methods --- Arrhythmias, Cardiac - diagnosis --- Electrocardiography - methods --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Heart Diseases --- Pathologic Processes --- Investigative Techniques --- Heart Function Tests --- Electrodiagnosis --- Diagnostic Techniques and Procedures --- Pathological Conditions, Signs and Symptoms --- Cardiovascular Diseases --- Diagnostic Techniques, Cardiovascular --- Diseases --- Diagnosis --- Methods
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Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-.
Alkaloids --- Heterocyclic Compounds --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemicals and Drugs --- Methods --- Botany --- Chemistry --- Physical Sciences & Mathematics --- Earth & Environmental Sciences --- Plant Physiology --- Inorganic Chemistry --- Biochemistry --- Synthesis --- Chemistry, Organic. --- Synthesis. --- Organic chemistry --- Chemistry. --- Analytical chemistry. --- Biotechnology. --- Inorganic chemistry. --- Inorganic Chemistry. --- Analytical Chemistry. --- Chemistry, inorganic. --- Analytical biochemistry. --- Chemical engineering --- Genetic engineering --- Inorganic chemistry --- Inorganic compounds --- Analytic biochemistry --- Chemistry, Analytic --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Alkaloids - Synthesis
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Biomolecules in nature exhibit overwhelming one-handedness, often called homochirality, such as L-amino acids and D-sugars. Since the discovery of molecular chirality by Pasteur, the origins of chirality and the process le- ing to enantiopure biomolecules have attracted broad attention from many researchers. Several theories have been proposed for the origin of chirality in organic compounds, for example, left and right-circularly polarized light, sp- taneous absolute asymmetric synthesis, and chiral inorganic crystals such as quartz. However, the enantioenrichments induced by these mechanisms have been very low or even below detection levels. Thus, the process of ampli?cation of enantioenrichment is inevitable to reach enantiopure compounds. In 1953, Frank proposed a mechanism of asymmetric autocatalysis without mentioning any chemical structure. However, it then took over 40 years for us to discover asymmetric autocatalysis with ampli?cation of chirality in 1995. This book illustrates the recent aspects of ampli?cation of chirality by as- metric autocatalysis and by forming helical structures. The ?rst four chapters summarize experimental asymmetric autocatalysis with ampli?cation of en- tiopurity, the mechanism of asymmetric autocatalysis examined by NMR and calculation, the computer simulation models of the reaction mechanism of asymmetric autocatalysis, and the theoretical models of ampli?cation of c- rality. The last chapter deals with the ampli?cation of chirality by the f- mation of helical structures. However, the ampli?cation of enantiopurity in non-autocatalytic asymmetric reaction and the ampli?cation by enantiomer separation involving crystallization or sublimation are beyond the scope of this book.
Chemistry. --- Organic Chemistry. --- Organometallic Chemistry. --- Physical Chemistry. --- Chemistry, Organic. --- Physical organic chemistry --- Chimie --- Chimie organique --- Chimie organique physique --- Circular Dichroism --- Stereoisomerism --- Isomerism --- Spectrum Analysis --- Chemistry Techniques, Analytical --- Organic Chemistry Phenomena --- Investigative Techniques --- Chemical Phenomena --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemistry --- Physical & Theoretical Chemistry --- Chemistry --- Physical Sciences & Mathematics --- Autocatalysis. --- Chirality. --- Autocatalytic reaction --- Reaction, Autocatalytic --- Self-catalysis --- Organic chemistry. --- Organometallic chemistry. --- Physical chemistry. --- Stereochemistry --- Symmetry (Physics) --- Enantiomers --- Catalysis --- Chemistry, Physical organic. --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Organic chemistry --- Organometallic chemistry . --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Chemistry, Organometallic --- Metallo-organic chemistry --- Stereoisomerism.
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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
Cell Culture Techniques --- Antibody Formation --- Recombinant Proteins --- Cell culture --- Biotechnology --- Cellules --- Biotechnologie --- therapeutic use --- Culture --- Biochemistry --- Cytology --- Cellules--Culture --- Biotechnology. --- Cell culture. --- Electronic books. -- local. --- Proteins --- Immune System Processes --- Culture Techniques --- Amino Acids, Peptides, and Proteins --- Immune System Phenomena --- Clinical Laboratory Techniques --- Investigative Techniques --- Chemicals and Drugs --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Mechanical Engineering --- Engineering & Applied Sciences --- Bioengineering --- Chemistry. --- Biochemistry. --- Cell biology. --- Cell Biology. --- Biochemistry, general. --- Chemical engineering --- Genetic engineering --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Physical sciences --- Composition --- Cultures (Biology) --- Technique --- Cytology.
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Cell Separation --- Separation (Technology) --- Séparation (Technologie) --- Cell Separation. --- Cytological Techniques --- Clinical Laboratory Techniques --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Engineering --- Bioengineering --- Biomedical Engineering --- Health & Biological Sciences --- Chemical & Materials Engineering --- Mechanical Engineering --- Engineering & Applied Sciences --- Biotechnology. --- Chemistry. --- Analytical chemistry. --- Cell biology. --- Cell Biology. --- Analytical Chemistry. --- Chemical engineering --- Genetic engineering --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Analysis, Chemical --- Analytical chemistry --- Chemical analysis --- Metallurgical analysis --- Mineralogy, Determinative --- Physical sciences --- Chemistry, Analytic --- Chemistry, Technical --- Technology --- Cytology. --- Analytical biochemistry. --- Analytic biochemistry --- Biochemistry --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytic chemistry --- Chemistry --- Chemical separations --- Separation processes --- Separation science --- Separation technologies --- Separations, Chemical
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M. B. Nodwell S. A. Sieber ABPP Methodology: Introduction and Overview J. Krysiak R. Breinbauer Activity-Based Protein Profiling for Natural Product Target Discovery P. P. Geurink L. M. Prely G. A. van der Marel R. Bischoff H. S. Overkleeft Photoaffinity Labeling in Activity-Based Protein Profiling W. P. Heal E. W. Tate Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis Y.-G. Kim A. Saghatelian Functional Analysis of Protein Targets by Metabolomic Approaches. .
Proteomics --- Proteins --- Molecular Probe Techniques --- Biochemistry --- Genomics --- Microarray Analysis --- Biological Science Disciplines --- Microchip Analytical Procedures --- Amino Acids, Peptides, and Proteins --- Genetic Techniques --- Computational Biology --- Chemistry --- Investigative Techniques --- Genetics --- Biology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemicals and Drugs --- Chemistry Techniques, Analytical --- Natural Science Disciplines --- Disciplines and Occupations --- Protein Array Analysis --- Proteome --- Human Anatomy & Physiology --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Animal Biochemistry --- Chemistry - General --- Proteomics. --- Proteins. --- Proteids --- Chemistry. --- Pharmaceutical technology. --- Organic chemistry. --- Organic Chemistry. --- Pharmaceutical Sciences/Technology. --- Molecular biology --- Biomolecules --- Polypeptides --- Chemistry, Organic. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Organic chemistry --- Pharmaceutical technology --- Chemistry, Organic
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J. S. Hayes E. M. Czekanska R. G. Richards The Cell-Surface Interaction Stefanie Michaelis Rudolf Robelek achim Wegener Studying Cell-Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques Kyobum Kim Diana M. Yoon Antonios G. Mikos F. Kurtis Kasper Harnessing Cell-Biomaterial Interactions for Osteochondral Tissue Regeneration Mathias Wilhelmi Bettina Giere Michael Harder Interaction of Cells with Decellularized Biological Materials Arie Bruinink Reto Luginbuehl Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations Margit Schulze Edda Tobiasch Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues Julia Will Lutz-Christian Gerhardt Aldo R. Boccaccini Bioactive Glass-Based Scaffolds for Bone Tissue Engineering Tali Re’em Smadar Cohen Microenvironment Design for Stem Cell Fate Determination Sonja Kress Anne Neumann Birgit Weyand Cornelia Kasper Stem Cell Differentiation Depending on Different Surfaces Frank Witte Ivonne Bartsch Elmar Willbold Designing the Biocompatibility of Biohybrids K. Wiegandt C. Goepfert R. Pörtner R. Janssen Interaction of Cartilage and Ceramic Matrix Debarun Das Ziyang Zhang Thomas Winkler Meenakshi Mour Christina I. Günter Michael M. Morlock Hans-Günther Machens Arndt F. Schilling Bioresorption and Degradation of Biomaterials.
Cell Physiological Processes --- Culture Techniques --- Clinical Laboratory Techniques --- Cell Physiological Phenomena --- Phenomena and Processes --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cell Communication --- Cell Culture Techniques --- Tissue Engineering --- Mechanical Engineering --- Engineering & Applied Sciences --- Bioengineering --- Tissue engineering. --- Cell culture. --- Chemistry. --- Biotechnology. --- Cell biology. --- Biomaterials. --- Cell Biology. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemical engineering --- Genetic engineering --- Physical sciences --- Cultures (Biology) --- Cytology --- Regenerative medicine --- Tissue culture --- Technique --- Cytology. --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)
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Time-Dependent Density Functional Response Theory for Electronic Chiroptical Properties of Chiral Molecules, by Jochen Autschbach, Lucia Nitsch–Velasquez, and Mark Rudolph; Recent Theoretical and Experimental Advances in the Electronic Circular Dichroisms of Planar Chiral Cyclophanes, by Yoshihisa Inoue and Tadashi Mori; G-C Content Independent Long-Range Charge Transfer Through DNA, by Kiyohiko Kawai and Tetsuro Majima; Transfer of Chirality for Memory and Separation, by Rosaria Lauceri, Alessandro D’Urso, Angela Mammana and Roberto Purrello; Vibrational Circular Dichroism Spectroscopy 4 of Chiral Molecules, by Guochun Yang and Yunjie Xu; Spin Selective Electron Transmission Through Monolayers of Chiral Molecules, by Ron Naaman and Zeev Vager; Chiral Control of Current Transfer in Molecules, by Vered Ben-Moshe, David N. Beratan, Abraham Nitzan and Spiros S. Skourtis; Spin-Polarized Electron Induced Asymmetric Reactions in Chiral Molecules, by Richard A. Rosenberg.
Electromagnetic Phenomena --- Elementary Particles --- Physics --- Models, Theoretical --- Natural Science Disciplines --- Investigative Techniques --- Physical Phenomena --- Phenomena and Processes --- Disciplines and Occupations --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Models, Molecular --- Electrons --- Magnetics --- Chemistry --- Physical Sciences & Mathematics --- Physical & Theoretical Chemistry --- Molecules --- Chirality. --- Magnetic properties. --- Chemistry. --- Organic chemistry. --- Physical chemistry. --- Chemistry, Physical and theoretical. --- Theoretical and Computational Chemistry. --- Organic Chemistry. --- Physical Chemistry. --- Stereochemistry --- Symmetry (Physics) --- Enantiomers --- Chemistry, Organic. --- Chemistry, Physical organic. --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Organic chemistry --- Physical sciences --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry
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Angelo Gavezzotti Computational Studies of Crystal Structure and Bonding Piero Macchi Cryo-Crystallography: Diffraction at Low Temperature and More Malcolm I. McMahon High-Pressure Crystallography Panče Naumov Chemical X-Ray Photodiffraction: Principles, Examples, and Perspectives Kenneth D. M. Harris Powder Diffraction Crystallography of Molecular Solids.
X-ray crystallography --- X-Ray Diffraction --- Chemistry, Physical --- Investigative Techniques --- Chemistry Techniques, Analytical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Natural Science Disciplines --- Disciplines and Occupations --- Methods --- Crystallography --- Crystallography, X-Ray --- Chemical & Materials Engineering --- Physical Sciences & Mathematics --- Engineering & Applied Sciences --- Analytical Chemistry --- Materials Science --- Chemistry - General --- X-ray crystallography. --- Crystallography. --- Leptology --- Chemistry. --- Analytical chemistry. --- Physical chemistry. --- Analytical Chemistry. --- Physical Chemistry. --- Physical sciences --- Mineralogy --- Analytical biochemistry. --- Chemistry, Physical organic. --- Crystallography and Scattering Methods. --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis
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